Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer’s disease

Abstract Background Accelerated long-term forgetting has been identified in preclinical Alzheimer’s disease (AD) and is attributed to a selective impairment of memory consolidation which the hippocampus plays key role. As blood may contain multiple senescence-related factors that involved neurogenesis synaptic plasticity hippocampus, we tested whether there an association between blood-borne accelerated asymptomatic individuals from families with autosomal dominant AD (ADAD). Methods We analyzed data 39 participants ( n = 18 ADAD mutation carriers, 21 non-carriers) Chinese Familial Disease Network (CFAN) study. Long-term rates were calculated based on recall or recognition two materials (word list complex figure) at three delays comprising immediate, 30 min, 7 days. Peripheral concentrations candidate pro-aging (CC chemokine ligand 11 [CCL11] monocyte chemotactic protein 1 [MCP1]) rejuvenation (growth differentiation factor [GDF11], thrombospondin-4 [THBS4], secreted acidic rich cysteine like [SPARCL1]) evaluated all participants. Results Despite normal performance standard 30-min delayed testing, carriers exhibited verbal visual material over days comparison matched non-carriers. In whole sample, lower plasma THBS4 was associated (β −0.46, p 0.002), figure −0.44, 0.004), −0.37, 0.010). Additionally, higher GDF11 CCL11 both (GDF11 versus recall: β 0.39, 0.007; recognition: 0.44, 0.002). Conclusions cognitive feature presymptomatic AD. Senescence-related factors, especially THBS4, GDF11, CCL11, be promising biomarkers for prediction forgetting.